Embedded Files
Gamsjäger L, Cirone KM, Schluessel S, Campsall M, Herik A, Lahiri P, Young D, Dufour A, Sapountzis P, Otani S, Gomez DE, Windeyer MC, Cobo ER. Host innate immune responses and microbiome profile of neonatal calves challenged with Cryptosporidium parvum and the effect of bovine colostrum supplementation. Front Cell Infect Microbiol. 2023 May 3;13:1165312. doi: 10.3389/fcimb.2023.1165312. PMID: 37207189; PMCID: PMC10189047.
Das N, de Almeida LGN, Derakhshani A, Young D, Mehdinejadiani K, Salo P, Rezansoff A, Jay GD, Sommerhoff CP, Schmidt TA, Krawetz R, Dufour A. Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis. Nat Commun. 2023 Apr 6;14(1):1910. doi: 10.1038/s41467-023-37598-3. PMID: 37024468; PMCID: PMC10079686.
Ameen SS, Griem-Krey N, Dufour A, Hossain MI, Hoque A, Sturgeon S, Nandurkar H, Draxler DF, Medcalf RL, Kamaruddin MA, Lucet IS, Leeming MG, Liu D, Dhillon A, Lim JP, Basheer F, Zhu HJ, Bokhari L, Roulston CL, Paradkar PN, Kleifeld O, Clarkson AN, Wellendorph P, Ciccotosto GD, Williamson NA, Ang CS, Cheng HC. N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection. Mol Cell Proteomics. 2023 Apr 6;22(5):100543. doi: 10.1016/j.mcpro.2023.100543. Epub ahead of print. PMID: 37030595; PMCID: PMC10199228.
Agbani EO, Chow L, Nicholas J, Skeith L, Schneider P, Gregory A, Mahe E, Yamaura L, Young D, Dufour A, Paul PP, Walker AM, Mukherjee PG, Poole AW, Poon MC, Lee A. Overexpression of facilitative glucose transporter-3 and membrane procoagulation in maternal platelets of preeclamptic pregnancy. J Thromb Haemost. 2023 Mar 22:S1538-7836(23)00244-1. doi: 10.1016/j.jtha.2023.03.014. Epub ahead of print. PMID: 36963633.
Douchin J, Nogueira de Almeida LG, Gonneaud A, Boisvert FM, Dufour A, Giroux V. A153 PYCRL LACTYLATION AS A POTENTIAL REGULATOR OF CANCER STEM CELL METABOLISM IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA (ESCC). J Can Assoc Gastroenterol. 2023 Mar 7;6(Suppl 1):3–4. doi: 10.1093/jcag/gwac036.153. PMCID: PMC9991381.
de Almeida LGN, Rosentreter R, Hirota S, Lu C, Dufour A. A38 INVESTIGATION OF POST-TRANSLATIONAL MODIFICATIONS IN SERUM OF CROHN’S DISEASE PATIENTS USING A PROTEOMICS APPROACH. J Can Assoc Gastroenterol. 2023 Mar 7;6(Suppl 1):21. doi: 10.1093/jcag/gwac036.038. PMCID: PMC9991388.
Voigt AL, Dardari R, Lara NLM, He T, Steele H, Dufour A, Orwig KE, Dobrinski I. Multiomics approach to profiling Sertoli cell maturation during development of the spermatogonial stem cell niche. Mol Hum Reprod. 2023 Feb 28;29(3):gaad004. doi: 10.1093/molehr/gaad004. PMID: 36688722; PMCID: PMC9976880.
Holani R, Rathnayaka C, Blyth GAD, Babbar A, Lahiri P, Young D, Dufour A, Hollenberg MD, McKay DM, Cobo ER. Cathelicidins Induce Toll-Interacting Protein Synthesis to Prevent Apoptosis in Colonic Epithelium. J Innate Immun. 2022 Sep 16:1-18. doi: 10.1159/000526121. Epub ahead of print. PMID: 36116427.
Koistinen H, Kovanen RM, Hollenberg MD, Dufour A, Radisky ES, Stenman UH, Batra J, Clements J, Hooper JD, Diamandis E, Schilling O, Rannikko A, Mirtti T. The roles of proteases in prostate cancer. IUBMB Life. 2023 Jun;75(6):493-513. doi: 10.1002/iub.2700. Epub 2023 Jan 4. PMID: 36598826; PMCID: PMC10159896.
Yamaura L, Young D, Skeith L, Monument MJ, Jenne CN, Dufour A, Schneider P, Agbani EO. Heightened Procoagulation after Post-Operative Thromboprophylaxis Completion in Patients with Metastatic Bone Disease from Primary Colorectal Cancer. J Clin Med. 2022 Dec 13;11(24):7397. doi: 10.3390/jcm11247397. PMID: 36556013; PMCID: PMC9784178.
Sinha S, Sparks HD, Labit E, Robbins HN, Gowing K, Jaffer A, Kutluberk E, Arora R, Raredon MSB, Cao L, Swanson S, Jiang P, Hee O, Pope H, Workentine M, Todkar K, Sharma N, Bharadia S, Chockalingam K, de Almeida LGN, Adam M, Niklason L, Potter SS, Seifert AW, Dufour A, Gabriel V, Rosin NL, Stewart R, Muench G, McCorkell R, Matyas J, Biernaskie J. Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer. Cell. 2022 Dec 8;185(25):4717-4736.e25. doi: 10.1016/j.cell.2022.11.004. PMID: 36493752; PMCID: PMC9888357.
Roy S, Ann Labrecque A, Dufour A, Brechenmacher L, Young D, Chen SA, Le D, Cooper S, Gibson P, Clarke AE, Skeith L; First-in-Human Detection of Romiplostim Drug Levels in Cord Blood, Breastmilk and Blood in a Woman with ITP and Her Newborn Infant. Blood 2022; 140 (Supplement 1): 2697–2698. doi: https://doi.org/10.1182/blood-2022-167038
Szczepanski HE, Flannigan KL, Mainoli B, Alston L, Baruta GM, Lee JW, Venu VKP, Shearer J, Dufour A, Hirota SA. NR4A1 modulates intestinal smooth muscle cell phenotype and dampens inflammation-associated intestinal remodeling. FASEB J. 2022 Nov;36(11):e22609. doi: 10.1096/fj.202101817RR. PMID: 36250380.
Lail SS, Arnold CR, de Almeida LGN, McKenna N, Chiriboga JA, Dufour A, Warren AL, Yates RM. Hox-driven conditional immortalization of myeloid and lymphoid progenitors: Uses, advantages, and future potential. Traffic. 2022 Nov;23(11):538-553. doi: 10.1111/tra.12869. Epub 2022 Oct 4. PMID: 36117140.
Das, N., de Almeida, L.G.N., Derakhshani, A. et al. Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis. Nat Commun 14, 1910 (2023). https://doi.org/10.1038/s41467-023-37598-3
Rabbani M, Satriano A, Garcia J, Thompson S, Wu JN, Pejevic M, Anderson T, Dufour A, Phillips A, White JA. Limits of Cardiovascular Adaptation During an Extreme Ultramarathon: Insights From Serial Multidimensional, Multiparametric CMR. JACC Case Rep. 2022 Sep 7;4(17):1104-1109. doi: 10.1016/j.jaccas.2022.05.028. PMID: 36124158; PMCID: PMC9481903.
Voigt AL, Dardari R, Su L, Lara NLM, Sinha S, Jaffer A, Munyoki SK, Alpaugh W, Dufour A, Biernaskie J, Orwig KE, Dobrinski I. Metabolic transitions define spermatogonial stem cell maturation. Hum Reprod. 2022 Aug 25;37(9):2095-2112. doi: 10.1093/humrep/deac157. PMID: 35856882; PMCID: PMC9614685.
Mudigonda S, Shah S, Das N, Corpuz JM, Ninkovic N, Al-Jezani N, Underhill TM, Salo PT, Mitha AP, Lyons FG, Cho R, Schmidt TA, Dufour A, Krawetz RJ. Proteoglycan 4 is present within the dura mater and produced by mesenchymal progenitor cells. Cell Tissue Res. 2022 Sep;389(3):483-499. doi: 10.1007/s00441-022-03647-4. Epub 2022 Jun 15. PMID: 35704103.
Xue J, Lin Y, Oo D, Zhang J, Zardynezhad A, de Jesus FN, Stephens M, de Almeida LGN, Young D, Dufour A, Liao S. Lymph-derived chemokines direct early neutrophil infiltration in the lymph nodes upon Staphylococcus aureus skin infection. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2111726119. doi: 10.1073/pnas.2111726119. Epub 2022 Aug 1. PMID: 35914162; PMCID: PMC9371737.
Ignacio A, Shah K, Bernier-Latmani J, Köller Y, Coakley G, Moyat M, Hamelin R, Armand F, Wong NC, Ramay H, Thomson CA, Burkhard R, Wang H, Dufour A, Geuking MB, McDonald B, Petrova TV, Harris NL, McCoy KD. Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization. Immunity. 2022 Jul 12;55(7):1250-1267.e12. doi: 10.1016/j.immuni.2022.05.014. Epub 2022 Jun 15. PMID: 35709757.
de Almeida LGN, Thode H, Eslambolchi Y, Chopra S, Young D, Gill S, Devel L, Dufour A. Matrix Metalloproteinases: From Molecular Mechanisms to Physiology, Pathophysiology, and Pharmacology. Pharmacol Rev. 2022 Jul;74(3):712-768. doi: 10.1124/pharmrev.121.000349. PMID: 35738680.
Anowai, A., Chopra, S., Mainoli, B., Young, D., Dufour, A. (2022). N-Terminomics/TAILS of Tissue and Liquid Biopsies. In: Geddes-McAlister, J. (eds) Proteomics in Systems Biology. Methods in Molecular Biology, vol 2456. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2124-0_7
de Almeida, L. G. N., Young, D., Chow, L., Nicholas, J., Lee, A., Poon, M.-C., Dufour, A., et al. (2022). Proteomics and Metabolomics Profiling of Platelets and Plasma Mediators of Thrombo-Inflammation in Gestational Hypertension and Preeclampsia. Cells, 11(8), 1256. MDPI AG. Retrieved from http://dx.doi.org/10.3390/cells11081256
Derakhshani A, Javadrashid D, Hemmat N, Dufour A, Solimando AG, Abdoli Shadbad M, Duijf PHG, Brunetti O, Silvestris N, Baradaran B. Identification of Common and Distinct Pathways in Inflammatory Bowel Disease and Colorectal Cancer: A Hypothesis Based on Weighted Gene Co-Expression Network Analysis. Front Genet. 2022 Mar 31;13:848646. doi: 10.3389/fgene.2022.848646.
Douchin J, Nogueira de Almeida L, Gonneaud A, Boisvert F, Dufour A, Giroux V. A3 TARGETING PROLINE METABOLISM TO OVERCOME TREATMENT RESISTANCE IN ESOPHAGEAL CANCER. J Can Assoc Gastroenterol. 2022 Feb 21;5(Suppl 1):3–5. doi: 10.1093/jcag/gwab049.002.
Pettersen, V.K., Dufour, A. & Arrieta, MC. Metaproteomic profiling of fungal gut colonization in gnotobiotic mice. anim microbiome 4, 14 (2022)
Ueno A, Jijon HB, Peng R, Sparksman S, Mainoli B, Filyk A, Li Y, Wilson S, Novak K, Panaccione R, Hirota S, Dufour A, Lu C, Beck PL. Association of Circulating Fibrocytes With Fibrostenotic Small Bowel Crohn's Disease. Inflamm Bowel Dis. 2022 Feb 1;28(2):246-258. doi: 10.1093/ibd/izab157..
Skeith, L.; Hurd, K.; Chaturvedi, S.; Chow, L.; Nicholas, J.; Lee, A.; Young, D.; Goodyear, D.; Soucie, J.; Girard, L.; Dufour, A.; Agbani, E.O. Hypercoagulability and Inflammatory Markers in a Case of Congenital Thrombotic Thrombocytopenic Purpura Complicated by Fetal Demise. J. Clin. Med. 2022, 11, 7115. https://doi.org/10.3390/jcm11237115
Hassanian H, Asadzadeh Z, Baghbanzadeh A, Derakhshani A, Dufour A, Khosroshahi NR, Najafi S, Brunetti O, Silvestris N, Baradaran. The expression pattern of immune checkpoints after chemo/radiotherapy in the tumor microenvironment. Frontiers in Immunology, 2022: 1-17.
Voigt AL, Dardari R, Su L, Lara NLM, Sinha S, Jaffer A, Munyoki SK, Dufour A, Biernaskie J, Orwig KE, Dobrinski I. Metabolic transitions define spermatogonial stem cell maturation. Human Reproduction, 2022: 1-18.
de Almeida LGN, Thode H, Eslambolchi Y, Chopra S, Young D, Gill S, Devel L, Dufour A. Matrix Metalloproteinases: From Molecular Mechanisms to Physiology, Pathophysiology, and Pharmacology. Pharmacological Reviews, 2022, 74(3): 712-768.
Ignacio A, Shah K, Bernier-Latmani J, Koller Y, Coakley G, Moyat M, Hamelin R, Armand F, Wong NC, Ramay H, Thomson CA, Burkhard R, Wang H, Dufour A, Geuking MB, McDonald B, Petrova TV, Harris NL, McCoy KD. Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization. Immunity, 2022, 55: 1-18.
Mudigonda S, Shah, S, Das N, Corpuz JM, Ninkovic N, Al-Jezani N, Underhill TM, Salo PT, Mitha AP, Lyons FG, Cho R, Schmidt TA, Dufour A, Krawetz R. Proteoglycan 4 is present within the dura mater and produced by mesenchymal progenitor cells. Cell and Tissue Research, 2022, published online June 15 2022.
Anowai A, Chopra S, Mainoli B, Young D, Dufour A. N-terminomics/TAILS of Tissue and Liquid Biopsies. Methods in Molecular Biology, 2022, 2456: 85-94.
de Almeida LGN, Young D, Chow L, Nicholas J, Lee A, Poon MC, Dufour A, Agbani EO. Proteomics and Metabolomics Profiling of Platelets and Plasma Mediators of Thrombo-Inflammation in Gestational Hypertension and Preeclampsia. Cells, 2022, 11(8): 1256-1280.
Derakshani A, Javadrashid D, Hemmat N, Dufour A, Solimando AG, Abdoli Shadbad M, Duijf PHG, Brunetti O, Silvestris N, Baradaran B. Identification of Common and Distinct Pathways in Inflammatory Bowel Disease and Colorectal Cancer: A Hypothesis Based on Weighed Gene Co-Expression Network Analysis. Frontiers in Genetics, 2022, 13: 848646, 1-12.
Gomes KP, Jasli AS, de Almeida LGN, Ballasy NN, Edalat P, Shandilya R, Young D, Belke D, Shearer J, Dufour A, Patel VB. Proteomic Analysis Suggests Altered Mitochondrial Metabolic Profile Associated with Diabetic Cardiomyopathy. Frontiers in Cardiovascular Medicine, 2022, 9: 791700, 1-15.
Pettersen VK, Dufour A, Arrieta MC. Metaproteomic Profiling of Fungal Gut Colonization in Gnotobiotic Mice. Animal Microbiome, 2022, 4(1): 14, 1-17.
Pettersen VK, Antunes LCM, Dufour A, Arrieta MC. Inferring early-life host and microbiome functions by mass spectrometry-based metaproteomics and metabolomics. Computational and Structural Biotechnology Journal, 2022, 20: 274-286.
Sinha S, Rosin NL, Arora R, Labit E, Jaffer A, Cao L, Farias R, Nguyen AP, de Almeida LGN, Dufour A, Bromley A, McDonal B, Gillrie MR, Fritzler MJ, Yipp BG, Biernaskie J. Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19. Nature Medicine, 2022, 28(1): 201-211.
Ueno A, Jijon HB, Peng R, Sparksman S, Mainoli B, Filyk A, Li Y, Wilson S, Novak K, Panaccione R, Hirota S, Dufour A, Lu C, Beck PL. Association of Circulating Fibrocytes with Fibrostenoic Small Bowell Crohn’s Disease. Inflammatory Bowel Diseases, 2022, 28(2): 246-258.
Das N, Menon NG, de Almeida LGN, Woods PS, Heynen ML, Jay GD, Caffery B, Jones L, Krawetz R, Schmidt TA, Dufour A. Proteomics Analysis of Tears and Saliva from Sjogren’s Syndrome Patients. Frontiers in Pharmacology, 2021, 12: 787193, 1-17.
Chadha A, Moreau F, Wang S, Dufour A, Chadee K. Entamoeba histolytica activation of caspase-1 degrades cullin that attenuates NF-κB dependent signaling from macrophages. PLOS Pathogens, 2021, 17(9): e1009936, 1-25.
Wang L*, Main K*, Wang H, Julien O*, Dufour A*, Biochemical Tools for Tacking Proteolysis. Journal of Proteome Research, 2021, 20(12): 5264-5279.
Baddam P, Young D, Dunsmore G, Nie C, Eaton F, Elahi S, Jovel J, Adesida AB, Dufour A and Daniel Graf. Nasal septum deviation as the consequence of BMP-controlled changes to cartilage properties. Frontiers in Cell and Developmental Biology, 2021, 9: 696545, 1-19.
Michi AN, Yipp BG, Dufour A, Lopes F, Proud D. PGC-1α mediates a metabolic hhost defense response in human airway epithelium during rhinovirus infections. Nature Communications, 2021, 12(1): 3669, 1-19.
Shin W, Alpaugh W, Hallihan LJ, Sinha S, Crowther E, Martin GR, Scheidl-Yee T, Yang X, Yoon G, Goldsmith T, Berger ND, de Almeida LGN, Dufour A, Dobrinski I, Weinfeld M, Jirik FR, Biernaskie J. PNKP is required for maintaining the integrity of progenitor cell populations in adult mice. Life Science Alliance, 2021, 4(9): e202000790.
Juurikka K, Dufour A, Pehkonen K, Mainoli B, Campioni Rodrigues P, Solis N, Klein T, Nyberg P, Overall CM, Salo T and Astrom P. MMP8 increases tongue carcinoma cell-cell adhesion and diminishes migration via cleavage of anti-adhesive FXYD5. Oncogenesis, 2021, 10(5): 1-14.
Lozinski B, de Almeida L, Silva C, Dong Y, Brown D, Chopra S, Yong WV, Dufour A. Exercise rapidly alters proteomes in mice following spinal cord demyelination. Scientific Reports, 2021, 11(1): 7239, 1-16.
Begum S, Moreau F, Dufour A, Chadee K. Entamoeba histolytica exploits the autophagy pathway in macrophages to trigger inflammation in disease pathogenesis. Mucosal Imunology, 2021, 12: 1-17.
Menon NG, Goyal R, Lema C, Woods PS, Tanguay AP, Morin AA, Das N, Jay GD, Krawetz RJ, Dufour A, Shapiro LH, Redfern RL, Ghosh M, Schmidt TA. Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation. Experimental Eye Research, 2021, 208,108628: 1-10.
Mishra MK, Rawji KS, Keough MB, Kappen J, Dowlatabadi R, Vogel HJ, Chopra S, Distefano-Gagne F, Dufour A, Gosselin D, Yong WV. Harnessing the benefits of neuroinflammation: Generation of macrophages/microglia with prominent remyelinating properties. Journal of Neuroscience, 2021, 41(15): 3366-3385.
Hassan A, Iftinca M, Young D, Flynn R, Agosti F, Abdullah N, Defaye M, Scott MGH, Dufour A, Altier C. TRPV1 Activation Promotes β-arrestin2 Interaction with the Ribosomal Biogenesis Machinery in the Nucleolus: Implications for p53 Regulation and Neurite Outgrowth. International Journal of Molecular Sciences, 2021, 22(5): 2280-2297.
Chopra S, Myers Z, Sekhon H, Dufour A. The Nerves to Conduct a Multiple Sclerosis Crime Investigation. International Journal of Molecular Sciences, 2021, 22(5): 2498-2516.
Das N, Benko C, Gill S, Dufour A. The pharmacological TAILS of Matrix Metalloproteinases and their inhibitors. Pharmaceuticals, 2021, 14(1): 31-41.
Mainoli B, Hirota S, Edginton-Mitchell L, Lu C, Dufour A, Proteomics and Imaging in Crohn’s Disease: TAILS of Unlikely Allies. Trends in Pharmacological Sciences, 2020: 41(2): 74-84.
Anderson BM, de Almeida LGN, Young D, Dufour A*, Edginton-Mitchell* (*Co-Senior Author). N-Terminomics/TAILS Profiling of Macrophages after Chemical Inhibition of Legumain. Biochemistry, 2019; 59(3): 329-340.
Gordon MH, Anowai A, Young D, Das N, Campden RI, Sekhon H, Myers Z, Mainoli B, Chopra S, Thuy-Boun PS, Kizhakkedathu J, Bindra G, Jijon HB, Heitman S, Yates R, Wolan DW, Edgington-Mitchell LE, MacNaughton WK, Dufour A. N-terminomics/TAILS profiling of proteases and their substrates in ulcerative colitis. ACS Chemical Biology, 2019; 14(11): 2471-2483
Fallata AM, Wyatt RA, Levesque JM, Dufour A, Overall CM, Crawford BD. Intracellular Localization in Zebrafish Muscle and Conserved Sequence Features Suggest Roles for Gelatinase A Moonlighting in Sarcomere Maintenance. Biomedecines, 2019, 7(4); 93-105
Young D*, Das N*, Anowai A*, Dufour A. Matrix Metalloproteases as Influencers of the Cells’ Social Media. International Journal of Molecular Sciences, 2019; 20: 3847, 1-20
Motta JP, Denadai-Souza A, Sagnat D, Guiraud L, Edir A, Bonnart C, Sebbag M, Rousset P, Lapeyre A, Seguy C, Mathurine-Thomas N, Galipeau HJ, Bonnet D, Alric L, Buret AG, Wallace JL, Dufour A, Verdu EF, Hollenberg MD, Oswald E, Serino M, Deraison C, Vergnolle N. Active thrombin produced by the intestinal epithelium controls mucosal biofilm. Nature Communications, 2019; 10(1): 3224.
Chopra S, Overall CM, Dufour A. Matrix metalloproteinases in the CNS: Interferons get nervous. Cellular and Molecular Life Sciences, 2019, 76(16): 3083-3095.
Das N, Schimdt T, Krawetz R, Dufour A. Proteoglycan 4: From Mere Lubricant to Regulator of Tissue Homeostasis and Inflammation: Does proteoglycan 4 have the ability to buffer the inflammatory response? Bioessays, 2019; 41(1): e1800166.
Mallia-Milanes B, Dufour A, Philp C, Solis N, Klein T, Fischer M, Bolton CE, Shapiro SD, Overall CM, Johnson SR. TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations. American Journal of Lung and cellular Molecular Physiology, 2018; 315: 1003-1014.
Dufour A, Bellac C, Eckhard U, Solis N, Klein T, Kappelhoff R, Fortelny N, Jobin P, Rozmus J, Mark J, Pavlidis P, Dive V, Barbour S, Overall CM. C-terminal truncation of interferon-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease. Nature Communications, 2018, 9(1): 2416, 1-18.
Klein T, Eckhard U, Dufour A, Solis N, Overall CM. Protease Cleavage-mechanisms, Function, and “Omic” Approaches for a Near-Ubiquitous Posttranslational Modification. Chemical Reviews, 2018, 118(3):1137-1168.
Jagdeo JM, Dufour A, Klein T, Solis N, Kleifled O, Kizhakkedathu J, Luo H, Overall CM, Jan E. N-terminomics TAILS identifies host cell substrates of poliovirus and coxsackievirus B3 3C proteinases that modulate virus infection. Journal of Virology, 2018, 92(8); pii: JVI.02211-17.
Eckhard U*, Huesgen PF*, Schilling O*, Bellac CL, Butler G, Cox JH, Dufour A, Goebeler V, Kappelhoff R, auf dem Keller U, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM. Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14. Data in Brief, 2016; 7:299-310.
Klein T*, Fung S*, Renner F*, Blank M, Dufour A, Priatel J, Schweigler P, Melkko S, Viner R, Regnier C, Turvey S, Overall CM. The paracaspase MALT1 puts the brake on NF-κB signaling by cleaving HOIL1 and terminating linear ubiquitination. Nature Communications, 2015; 6: 8777, 1-17.
Eckhard U*, Huesgen PF*, Schilling O*, Bellac CL, Butler G, Cox JH, Dufour A, Goebeler V, Kappelhoff R, auf dem Keller U, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM. Active site specificity of the matrix metalloproteinase family: proteomic identification of 4,300 cleavage sites by nine MMPs explored by structural and synthetic peptide cleavage analyses. Matrix Biology, 2015; S0945-053X(15)00129-8.
Jagdeo JM, Dufour A, Fung G, Luo H, Overall CM, Jan E. Heterogenous nuclear ribonucleoprotein M facilitates enterovirus infection. Journal of Virology, 2015; 89(14):7064-78.
Dufour A. Degradomics of matrix metalloproteinases in inflammatory diseases. Frontiers in Bioscience Scholar, 2015; 7(1): 150-167.
Barré O*, Dufour A*, Eckhard U*, Kappelhoff U*, Béliveau F, Leduc R, Overall CM. Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries. PLOSone, 2014; 9(9):e105984.
Bellac C, Dufour A, Krisinger M, Loonchanta A, Roberts C, Starr A, Lange P, Morrison C, auf dem Keller U, Burtnick L, Conway E, Overall CM Matrix Metalloproteinase-12 is essential for macrophages to resolve inflammation. Cell Reports, 2014; 9: 618-632.
Marchant D, Bellac C, Moraes TJ, Wadsworth S, Dufour A, Butler GS, Bilawchuk LM, Hendry RG, Robertson AG, Cheung C, Ng J, Ang L, Luo Z, Heilbron K, Norris M, Duan W, Bucyk T, Karpov A, Devel L, Georgiadis D, Hegele R, Luo H, Granville DJ, Dive V, McManus BM, and Overall CM. MMP12−A Metalloproteinase Transcription Factor with Antiviral Activity. Nature Medicine, 2014; 20(5):493-502
Evensen N, Kuscu C, Zarrabi K, Dufour A, Kadam P, Hu Y, Nguyen H, Pulkoski-Gross A, Bahou W, Zucker S, Cao J. Unraveling the Role of KIAA1199, A Novel Endoplasmic Reticulum Protein, in Cancer Cell Migration. Journal of the National Cancer Institute, 2014; 105(18):1402-16.
Dufour A, and Overall CM. Missing the target: Matrix Metalloproteinase Anti-Targets in Inflammation and Cancer. Trends in Pharmacological Sciences; 2013; 34(4);233-242.
Starr AE, Dufour A, Maier J, Overall CM. Biochemical analysis of matrix metalloproteinase activation of chemokines CCL15 and CCL23 and increased glycosaminoglycan binding of CCL16. Journal of Biological Chemistry, 2012; 287(8):5848-60.
Starr AE, Bellac CL, Dufour A, Goebeler V, Overall CM. Biochemical Characterization and N-terminomics Analysis of Leukolysin, the Membrane-type 6 Matrix Metalloprotease (MMP25): CHEMOKINE AND VIMENTIN CLEAVAGES ENHANCE CELL MIGRATION AND MACROPHAGE PHAGOCYTIC ACTIVITIES. Journal of Biological Chemistry, 2012; 287(16):13382-95.
Dufour A, Sampson N, Rizzo R, DeLeon J, Li J, Kuscu C, Zhi J, Jaber N, Liu E, Zucker S, Cao J (2011) Small molecule anti-cancer therapy targets the hemopexin domain of Matrix Metal loproteinase-9 (MMP-9). Cancer Research, 2011; 71(14):4977-88.
Pavlaki M, Zucker S, Dufour A, Calabrese N, Bahou W, Cao J. Furin functions as a nonproteolytic chaperone for Matrix Metalloproteinase-28: MMP-28 propeptide sequence requirement. Biochemistry Research International, 2011; 2011:630319.
Zarrabi K*, Dufour A*, Schmidt C, Kozarekar P, Zucker S, Cao J. Inhibition of matrix metalloproteinase 14 (MMP-14)-mediated cancer cell migration. Journal of Biological Chemistry, 2010; 286(38):33167-77.
Dufour A, Sampson N, Kuscu C, Zucker S, Cao J (2010) Role of Matrix Metalloproteinase-9 (MMP-9) dimers in cell migration: design of inhibitory peptides. Journal of Biological Chemistry, 2010; 285 (46): 35944-56.
Meredith J, Dufour A, Bruch M. Comparison of the structure and dynamics of the antibiotic peptide polymyxin B and the inactive nonapeptide in aqueous trifluoroethanol by NMR spectroscopy. Journal of Physical Chemistry B, 2009; 113(2): 544-551.
Zucker S, Schmidt C, Dufour A, Kaplab R. Park H, Jiang, W. ProMMP-2:TIMP-1 complexes identified in plasma of healthy individuals. Connective Tissue Research, 2009; 50(4): 223-231.
Botchkina I, Rowehl R, Rivadeneira D, Karpeh M, Crawford H, Dufour A, Ju J, Wang Y, Leyfman Y, Botchkina G. Phenotypic Subpopulations of Metastatic Colon Cancer Stem Cells: Genomic Analysis. Cancer Genomics & Proteomics, 2009; 6(1): 19-29.
Dufour A, Sampson N, Zucker S, Cao J. Role of the hemopexin domain of matrix metalloproteinases in cell migration. Journal of Cellular Physiology, 2008; 217(3): 643-651.
Rowehl R, Crawford H, Dufour A, Ju J, Botchkina G. Genomic Analysis of Prostate Cancer Stem Cells Isolated from a Highly Metastatic Cell Line. Cancer Genomics & Proteomics, 2008; 5(6): 301-10.
NON-REFEREED PUBLICATIONS
Dufour A Therapeutics agents in preclinical/clinical studies 2nd Protease inhibitors in Drug Discovery, Meeting report for Thomson Reuters Professional division, March 2016
Dufour A and Overall CM Cellular Downward Dog: The yoga limits of cell migration through the matrix International Society for Matrix Biology (ISMB) newsletter, November 2013
BOOK CHAPTERS
de Almeida LG and Dufour A Proteases are cut out to regulate acute and chronic inflammation. Elsevier 2021, accepted but not published yet.
Dufour A Degradomics of Matrix Metalloproteinases in Inflammatory Diseases. Frontiers in Bioscience (Scholar Edition), 2015; 7:150-167. (pubmed ID: 25961692)
Dufour A and Overall CM. Subtracting the matrix out of the equation: matrix metalloproteinases in immunity and diseases. From Biological Mechanisms to Therapeutic Opportunities, 1st edition, Hoboken, NJ, U.S.A., John Wiley & Sons, 2014
Dufour A and Overall CM Rock, paper and molecular scissors: a story of ECM remodeling and beyond. Extracellular Matrix: Pathobiology and Signaling, 1st edition, Berlin, Germany, Walter de Gruyter GMBH & CO. kg, 2012
PUBLISHED ABSTRACTS
(2022) J Douchin, L Nogueira de Almeida, A Gonneaud, F Boisvert, A Dufour, V Giroux. A3 TARGETING PROLINE METABOLISM TO OVERCOME TREATMENT RESISTANCE IN ESOPHAGEAL CANCER, Journal of the Canadian Association of Gastroenterology, 5 (supplement 1), 3, Oxford University Press.
(2022) N Abdullah, M Defaye, A Hassan, M Cumenal, M Iftinca, D Young, CL Ohland, A Dufour, K McCoy, C Altier. A230 THE ROLE OF THE MICROBIOTA IN NOCICEPTOR DEVELOPMENT AND PAIN SENSITIVITY, Journal of the Canadian Association of Gastroenterology, 5 (supplement 1), 121-122, Oxford University Press.
(2021) DK Kaushik, JH Hahn, C Silva, T Vo, A Dufour, V Yong. EMMPRIN is critical for CCR2+ monocytes migration into EAE/MS brains, Multiple Sclerosis Journal, 27 (supplement 1), 102, SAGE publications LTD.
(2021) C Lu, A Filyk, B Mainoli, I de Almeida, K Novak, R Panaccione, S Hirota, A Dufour. Serum Proteomics and Intestinal Ultrasound Differentiates Fibrostenotic and Inflammatory Crohn's Disease, Journal of Crohns & Colitis, 15, S221, Oxford University Press.
(2021) K Gomes, LGN de Almeida, N Ballasy, P Edalat, D Young, A Dufour, V Patel. Proteomic Analysis Suggests Altered Mitochondrial Metabolic Profile in Diabetic Cardiomyopathy, The FASEB journal, 35, John Wiley & Sons, Ltd.
(2021) A Filyk, B Mainoli, LGN de Almeida, Hirota, A Dufour, R Panaccione, S Wilson, KL Novak, C Lu. Su483 SERUM PROTEOMICS IDENTIFIES UNIQUE SIGNATURE TO DIFFERENTIATE FIBROSTENOTIC AND INFLAMMATORY CROHN'S DISEASE., Gastrotenterology, 160(6), S-712, WB Saunders.
(2021) B Scott, B Hayes, MS Poormasjedi-Meibod, M Fossey, E Erskine, J Soriano, M Tso, R Rosentreter, A Satriano, A Dufour, R Charbonneau, P Feuchter, S Rivest, J Flewitt, J Garcia, C West, J White, A Phillips. Orthostatic hypotension is associated with impaired cardiac structure and function after spinal cord injury, The FASEB journal, 35, John Wiley & Sons, Ltd.
(2021) AN Michi, B Yipp, A Dufour, F Lopes, D Proud. Multi-Omics Reveal Rhinovirus Strain-Specific Metabolic Signatures in Highly Differentiated Human Airway Epithelial Cells, TP105 BASIC MECHANISMS OF LUNG INFECTIONS: FROM SARS-COV-2 TO INFLUENZA, 35, A4190, American Thoracic Society.
(2021) LGN de Almeida, B Mainoli, AK Filyk, SA Hirota, C Lu, A Dufour. A37 EXPLORING THE PROTEOMICS DIFFERENCES IN CROHN’S DISEASE PATIENTS, Journal of the Canadian Association of Gastroenterology, 4 (supplement 1), 150-151, Oxford University Press.
(2021) HE Szczepanski, KL Flannigan, B Mainoli, L Alston, J Lee, GM Baruta, VP Venu, J Shearer, A Dufour, SA Hirota. A28 CHARACTERIZING THE ROLE OF NR4A1 IN THE REGULATION OF INTESTINAL SMOOTH MUSCLE CELL PHENOTYPE AND FUNCTION, Journal of the Canadian Association of Gastroenterology, 4 (supplement 1), 147-148, Oxford University Press.
(2021) D Kaushik, J Hahn, C Silva, T Vo, A Dufour, V Yong. Ccr2+ monocytes require emmprin for migration into eae/ms brains, Multiple Sclerosis Journal, 26 (supplement 3), 567-568, SAGE publications LTD.
(2020) HE Szczepanski, KL Flannigan, B Mainoli, L Alston, J Lee, GM Baruta, VP Venu, J Shearer, A Dufour, SA Hirota. A28 CHARACTERIZING THE ROLE OF NR4A1 IN THE REGULATION OF INTESTINAL SMOOTH MUSCLE CELL PHENOTYPE AND FUNCTION, Journal of the Canadian Association of Gastroenterology, 4 (supplement 1), 147-148, Oxford University Press.
(2020) N Al-Jezani, P Railton, J Powell, A Dufour, R Krawetz. GLOBAL PROTEOMIC AND GENOMIC EXPRESSION CHARACTERIZATION OF SYNOVIAL MESENCHYMAL STEM CELL FROM NORMAL AND OSTEOARTHRITIC KNEE JOINT, Orthopaedic Proceedings, 102 (supplement 6), 74, The British Editorial Society of Bone & Joint Surgery.
(2020) BA Scott, JE Soriano, RE Rosentreter, A Satriano, A Dufour, R Charbonneau, P Feuchter, S Rivest, R Sandonato, J Flewitt, J Garcia, C West, J White, A Phillips. Multiparametric cardiac magnetic resonance imaging of the heart in people with spinal cord injury, The FASEB Journal, 34 (supplement 1), 1-1, The Federation of American Societies for Experimental Biology.
(2020) AO Masson, BA Besler, D Young, A Dufour, WB Edwards, TM Underhill, RJ Krawetz. Enhancing articular cartilage regeneration by modulating the cell cycle within mesenchymal progenitors, Osteoarthritis and Cartilage, 28, S27, Elsevier.
(2019) K Juurikka, PÅström, A Dufour, M Sutinen, C Overall, T Salo. TERMINAL AMINE ISOTOPIC LABELING OF SUBSTRATES (TAILS) ANALYSIS REVEALS NOVEL POTENTIAL SUBSTRATES OF TUMOR SUPPRESSIVE MATRIX METALLOPROTEINASE-8 IN ORAL TONGUE CARCINOMA, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 128(1), e44, Mosby.
(2019) A Ueno, C Lu, H Jijon, KL Novak, S Wilson, SA Hirota, A Dufour, R Xavier, PL Beck. 865–Circulating Fibrocytes are Increased in Patients with Fibrostenotic Crohn's Disease, Gastroenterology, 156(6), S-193, WB Saunders.
(2019) C Lu, A Dufour, A Ueno, H Jijon, K Prowse, KL Novak, R Panaccione, SA Hirota. A13 PROTEINS AND FIBROSTENOTIC CROHN’S DISEASE; WHO SHOWED UP TO THE PARTY?, Journal of the Canadian Association of Gastroenterology, 2 (Supplement 2), 26-27, Oxford University Press.
(2019) Gordon M, Dufour A and MacNaughton W. A35 Neutrophil Elastase Proteolytic Activity Drives a Novel Pro-Resolution Cell Migration Phenotype. Journal of the Canadian Association of Gastroenterology, 2 (supplement 2), 70-71, Oxford University Press.
(2016) Mallia-Milanes B, Dufour A, Philp CJ, Bolton BE, Shapiro SD, Overall CM and Johnson SR . B58 Big and Bigger (Data): Omics and Biomarkers of COPD and Other Chronic Lung Diseases: Tails Proteomics in Two Species Identifies New Complement Components and Protease Inhibitors as MMP-12 Substrates in Human COPD Sputum. American Journal of Respiratory and Critical Care Medicine, 193, A4059, American Thoracic Society.
(2015) Mallia-Milanes B, Dufour A, Bailey H, Meakin G, Leme A, Bolton C, Shapiro SD, Overall CM and Johnson SR . S219 A Two Species Proteomics Approach to Determine MMP-12 Substrates in COPD. Thorax, 70 (supplement 3), A73-A74.
(2013) Evensen NA, Kuscu C, Dufour A, Zucker S and Cao J. B73: Unraveling The Role of a Novel Endoplasmic Reticulum Protein in Cancer Cell Migration. Cancer Research, 73 (supplement 3), B73.
(2012) Marchant D, Bellac C, Wadsworth S, Dufour A, Ng J, Luo Z, Overall CM and McManus BM. 518 Matrix Metalloproteinase-12 Regulates the Antiviral Immune Response During Viral Myocarditis Through Genetic Regulation and Interferon Degradation: Offering a Novel Antiviral Therapeutic Strategy. Canadian Journal of cardiology, 28 (5), S292, Elsevier.
(2009) Cao J, Kadam P, Nguyen HL, Dufour A and Zucker S. 2227: Cancer-Related Invasive Gene (CRIG): A Key Component of Breast Cancer Metastasis. Cancer Research, 69 (Supplement 9), 2227, American Association for Cancer Research.
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